Integrated Computer Systems for Monitoring of the Critically Ill

Conference PaperBiomedical Informatic

Science requirements and feasibility/design studies of a very-high-altitude aircraft for atmospheric research

The advantages and shortcomings of currently available aircraft for use in very high altitude missions to study such problems as polar ozone or stratosphere-troposphere exchange pose the question of whether to develop advanced aircraft for atmospheric research. To answer this question, NASA conducted a workshop to determine science needs and feasibility/design studies to assess whether and how those needs could be met. It was determined that there was a need for an aircraft that could cruise at an altitude of 30 km with a range of 6,000 miles with vertical profiling down to 10 km and back at remote points and carry a payload of 3,000 lbs

Wind Signatures In The X-Ray Emission-Line Profiles Of The Late-O Supergiant Zeta Orionis

X-ray line-profile analysis has proved to be the most direct diagnostic of the kinematics and spatial distribution of the very hot plasma around O stars. The Doppler-broadened line profiles provide information about the velocity distribution of the hot plasma, while the wavelength-dependent attenuation across a line profile provides information about the absorption to the hot plasma, thus providing a strong constraint on its physical location. In this paper, we apply several analysis techniques to the emission lines in the Chandra High Energy Transmission Grating Spectrometer (HETGS) spectrum of the late-O supergiant zeta Ori (O9.7 Ib), including the fitting of a simple line-profile model. We show that there is distinct evidence for blueshifts and profile asymmetry, as well as broadening in the X-ray emission lines of zeta Ori. These are the observational hallmarks of a wind-shock X-ray source, and the results for zeta Ori are very similar to those for the earlier O star, zeta Pup, which we have previously shown to be well fit by the same wind-shock line-profile model. The more subtle effects on the line-profile morphologies in zeta Ori, as compared to zeta Pup, are consistent with the somewhat lower density wind in this later O supergiant. In both stars, the wind optical depths required to explain the mildly asymmetric X-ray line profiles imply reductions in the effective opacity of nearly an order of magnitude, which may be explained by some combination of mass-loss rate reduction and large-scale clumping, with its associated porosity-based effects on radiation transfer. In the context of the recent reanalysis of the helium-like line intensity ratios in both zeta Ori and zeta Pup, and also in light of recent work questioning the published mass-loss rates in OB stars, these new results indicate that the X-ray emission from zeta Ori can be understood within the framework of the standard wind-shock scenario for hot stars

Predicting Foot Positions for Manual Materials Handling Tasks

Copyright © 2005 SAE International For many industrial tasks (push, pull, lift, carry, etc.), restrictions on grip locations and visibility constrain the hand and head positions and help to define feasible postures. In contrast, often the foot locations are minimally constrained and an ergonomics analyst can choose several different stances in selecting a posture to analyze. Also, because stance can be a critical determinant of a biomechanical assessment of the work posture, the lack of a valid method for placing the feet of a manikin with respect to the task compromises the accuracy of the analysis. To address this issue, foot locations and orientations were captured in a laboratory study of sagittal plane and asymmetric manual load transfers. A pilot study with four volunteers of varying anthropometry approached a load located on one of three shelves and transferred the load to one of six shelves. The data illustrate foot placements and behaviors that depend on pickup heights, the use of one or two hands to grasp the object, and the participantsʼ body dimensions. Two distinct pickup and delivery strategies were observed. Split stance, with one foot in front of the other, was markedly more frequent than parallel stance with the feet side by side. A statistical model was developed to predict foot placements at load pickup. This study confirms the importance of this topic and provides the basis for the much more comprehensive study that is now underway

Relativistic Quantum Mechanics and Relativistic Entanglement in the Rest-Frame Instant Form of Dynamics

A new formulation of relativistic quantum mechanics is proposed in the framework of the rest-frame instant form of dynamics with its instantaneous Wigner 3-spaces and with its description of the particle world-lines by means of derived non-canonical predictive coordinates. In it we quantize the frozen Jacobi data of the non-local 4-center of mass and the Wigner-covariant relative variables in an abstract (frame-independent) internal space whose existence is implied by Wigner-covariance. The formalism takes care of the properties of both relativistic bound states and scattering ones. There is a natural solution to the \textit{relativistic localization problem}. The non-relativistic limit leads to standard quantum mechanics but with a frozen Hamilton-Jacobi description of the center of mass. Due to the \textit{non-locality} of the Poincar\'e generators the resulting theory of relativistic entanglement is both \textit{kinematically non-local and spatially non-separable}: these properties, absent in the non-relativistic limit, throw a different light on the interpretation of the non-relativistic quantum non-locality and of its impact on foundational problems.Comment: 73 pages, includes revision

Windblown Pliocene Diatoms and East Antarctic Ice Sheet Retreat

Marine diatoms in tillites along the Transantarctic Mountains (TAMs) have been used to suggest a diminished East Antarctic Ice Sheet (EAIS) during Pliocene warm periods. Updated ice-sheet modelling shows significant Pliocene EAIS retreat, creating marine embayments into the Wilkes and Aurora basins that were conducive to high diatom productivity and rapid accumulation of diatomaceous sediments. Here we show that subsequent isostatic uplift exposed accumulated unconsolidated marine deposits to wind erosion. We report new atmospheric modelling utilizing Pliocene climate and derived Antarctic landscapes indicating that prevailing mid-altitude winds transported diatoms towards the TAMs, dominantly from extensive emerged coastal deposits of the Aurora Basin. This result unifies leading ideas from competing sides of a contentious debate about the origin of the diatoms in the TAMs and their link to EAIS history, supporting the view that parts of the EAIS are vulnerable to relatively modest warming, with possible implications for future sea-level rise

Should mentoring be routinely introduced into general dental practice to reduce the risk of occupational stress?

Introduction: Occupational stress within general dental practice can potentially have an adverse impact on a practitioner's wellbeing and the quality of healthcare provided by that individual. Mentoring has routinely been utilised in other professions for stress management, however, there is little in the dental literature discussing the benefits of mentorship on the reduction of occupational stress for dental practitioners. Aim: The aim of this study was to explore the perceptions of experienced foundation dental trainers within the Health Education, Kent, Surrey and Sussex postgraduate deanery as to the usefulness of routine mentoring as a tool to reduce occupational stress. Methods: Using a qualitative approach, six individual semi-structured interviews were undertaken. Recorded interviews were transcribed and transcriptions were analysed using thematic coding to identify overarching themes. Results: Both similarities and differences with the existing literature on routine mentoring within professional settings were identified. Foundation dental trainers were positive towards the concept of routine mentoring, although there was also a degree of scepticism regarding the potential uptake among colleagues. There was a perception that mentoring might more practically be used as a reactionary tool. Multiple potential barriers to routine mentoring were identified, included funding, scheduling and a lack of training. Conclusions: The analysis identified that currently, experienced foundation dental practitioners do not consider routine mentoring as a practical option in the prevention of occupational stress. The results would suggest that further education is required as to the benefits of routine mentoring as a strategy for occupational stress management. However, with additional resources buying time, a hybrid model of mentoring and coaching has significant potential in general dental practice

Subclinical infection of macaques and baboons with a baboon simarterivirus

Simarteriviruses (Arteriviridae: Simarterivirinae) are commonly found at high titers in the blood of African monkeys but do not cause overt disease in these hosts. In contrast, simarteriviruses cause severe disease in Asian macaques upon accidental or experimental transmission. Here, we sought to better understand the host-dependent drivers of simarterivirus pathogenesis by infecting olive baboons (n = 4) and rhesus monkeys (n = 4) with the simarterivirus Southwest baboon virus 1 (SWBV-1). Surprisingly, none of the animals in our study showed signs of disease following SWBV-1 inoculation. Three animals (two rhesus monkeys and one olive baboon) became infected and sustained high levels of SWBV-1 viremia for the duration of the study. The course of SWBV-1 infection was highly predictable: plasma viremia peaked between 1 × 107 and 1 × 108 vRNA copies/mL at 3–10 days post-inoculation, which was followed by a relative nadir and then establishment of a stable set-point between 1 × 106 and 1 × 107 vRNA copies/mL for the remainder of the study (56 days). We characterized cellular and antibody responses to SWBV-1 infection in these animals, demonstrating that macaques and baboons mount similar responses to SWBV-1 infection, yet these responses are ineffective at clearing SWBV-1 infection. SWBV-1 sequencing revealed the accumulation of non-synonymous mutations in a region of the genome that corresponds to an immunodominant epitope in the simarterivirus major envelope glycoprotein GP5, which likely contribute to viral persistence by enabling escape from host antibodies

Water at an electrochemical interface - a simulation study

The results of molecular dynamics simulations of the properties of water in an aqueous ionic solution close to an interface with a model metallic electrode are described. In the simulations the electrode behaves as an ideally polarizable hydrophilic metal, supporting image charge interactions with charged species, and it is maintained at a constant electrical potential with respect to the solution so that the model is a textbook representation of an electrochemical interface through which no current is passing. We show how water is strongly attracted to and ordered at the electrode surface. This ordering is different to the structure that might be imagined from continuum models of electrode interfaces. Further, this ordering significantly affects the probability of ions reaching the surface. We describe the concomitant motion and configurations of the water and ions as functions of the electrode potential, and we analyze the length scales over which ionic atmospheres fluctuate. The statistics of these fluctuations depend upon surface structure and ionic strength. The fluctuations are large, sufficiently so that the mean ionic atmosphere is a poor descriptor of the aqueous environment near a metal surface. The importance of this finding for a description of electrochemical reactions is examined by calculating, directly from the simulation, Marcus free energy profiles for transfer of charge between the electrode and a redox species in the solution and comparing the results with the predictions of continuum theories. Significant departures from the electrochemical textbook descriptions of the phenomenon are found and their physical origins are characterized from the atomistic perspective of the simulations.Comment: 29 pages, 15 figure